Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 4/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.33 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591027 | 0.85 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7591252 | 0.82 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7133759 | 0.82 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7587116 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7588840 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL1186123 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7585928 | 0.80 | ALDH1A1 (0.41) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL7591439 | 0.80 | ALDH1A1 (0.41) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL6813982 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL3650254 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506775-B1 | Treatment of a gastrointestinal disorder; a central nervous system (CNS) adverse conditions caused by Heliobacter pylori; or angiogenesis especially CNS disorders in a mammalian subject, especially humans. | PFIZER INC | 2003-01-14 | — | — | US | disclosed |
| US-6329396-B1 | TREATMENT OF GASTROINTESTINAL DISORDERS CENTRAL NERVOUS SYSTEM (CNS) DISORDERS; INFLAMMATORY DISEASE; EMESIS; URINARY INCONTINENCE; PAIN; MIGRAINE; SUNBURN; DISEASES, DISORDERS AND ADVERSE CONDITIONS CAUSED BY HELIOBACTER PYLORI; OR | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |
| EP-0861235-B1 | SUBSTITUTED BENZYLAMINOPIPERIDINE COMPOUNDS | PFIZER (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1114817-A1 | Substituted benzylamino piperidine compounds | PFIZER INC. (US) | 2001-07-11 | — | — | EP | disclosed |