SCHEMBL7130872

SCHEMBL7130872

Cn1c2c(c3cc(C(C)(C)C)ccc31)-c1ccccc1C2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 2/20 0.37
RORA P35398 1/20 0.37
RORC P51449 1/20 0.37
RORB Q92753 1/20 0.37
DNMT1 P26358 3/20 0.37
DRD2 P14416 1/20 0.37
DRD1 P21728 1/20 0.37
DRD5 P21918 1/20 0.37
DRD3 P35462 1/20 0.37
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
PLA2G1B P04054 1/20 0.36
NFKB1 P19838 1/20 0.36
CASP3 P42574 1/20 0.36
RAB9A P51151 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17806783 0.83 DNMT1 (0.35) PGRRORARORCRORBDNMT1
SCHEMBL19250379 0.83 DNMT1 (0.35) PGRRORARORCRORBDNMT1
SCHEMBL2978540 0.82 MEN1 (0.41) DRD2DRD1DRD5DRD3ALDH1A1
SCHEMBL17806770 0.81 CCNB2 (0.45) DRD2DRD1DRD5DRD3L3MBTL1
SCHEMBL17806767 0.80 DNMT1 (0.40) PGRRORARORCRORBDNMT1
SCHEMBL18457219 0.80 DNMT1 (0.40) PGRRORARORCRORBDNMT1
SCHEMBL7124714 0.79 GPR3 (0.45) DRD2DRD1DRD5DRD3ALDH1A1
SCHEMBL29371597 0.79 GPR3 (0.45) DRD2DRD1DRD5DRD3ALDH1A1
SCHEMBL23939875 0.78 PGR (0.38) PGRRORARORCRORBDRD2
SCHEMBL4373938 0.78 DRD2 (0.59) DRD2DRD1DRD5DRD3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200123357-A1 Olefin Polymer And Method For Preparing Same LG CHEM, LTD. (KR) 2020-04-23 US disclosed
US-10570221-B2 Metallocene supported catalyst and method for preparing polyolefin using the same LG CHEM, LTD. (KR) 2020-02-25 US disclosed
US-20190085100-A1 HYBRID SUPPORTED METALLOCENE CATALYST AND POLYOLEFIN PREPARATION METHOD USING SAME (As Amended) LG CHEM, LTD. (KR) 2019-03-21 US disclosed
US-20180223009-A1 OLEFIN-BASED POLYMER WITH EXCELLENT PROCESSABILITY LG CHEM, LTD. (KR) 2018-08-09 US disclosed
US-20180223009-A1 OLEFIN-BASED POLYMER WITH EXCELLENT PROCESSABILITY LG CHEM, LTD. (KR) 2018-08-09 US disclosed
US-20180194883-A1 ETHYLENE/ALPHA-OLEFIN COPOLYMERS HAVING EXCELLENT PROCESSABILITY LG CHEM, LTD. (KR) 2018-07-12 US disclosed
US-20180094084-A1 METHOD OF PREPARING SUPPORTED METALLOCENE CATALYST LG CHEM, LTD. (KR) 2018-04-05 US disclosed
US-20180094084-A1 METHOD OF PREPARING SUPPORTED METALLOCENE CATALYST LG CHEM, LTD. (KR) 2018-04-05 US disclosed
US-9926395-B2 Hybrid supported metallocene catalyst LG CHEM, LTD. (KR) 2018-03-27 US disclosed
US-9926395-B2 Hybrid supported metallocene catalyst LG CHEM, LTD. (KR) 2018-03-27 US disclosed
US-20160237188-A1 METHOD FOR PREPARING HYBRID SUPPORTED METALLOCENE CATALYST LG CHEM, LTD. (KR) 2016-08-18 US disclosed
US-20160222139-A1 METHOD OF PREPARING POLYOLEFIN, AND POLYOLEFIN PREPARED THEREBY (As Amended) LG CHEM, LTD. (KR) 2016-08-04 US disclosed
US-20160222139-A1 METHOD OF PREPARING POLYOLEFIN, AND POLYOLEFIN PREPARED THEREBY (As Amended) LG CHEM, LTD. (KR) 2016-08-04 US disclosed
US-20160168281-A1 A METALLOCENE COMPOUND, A CATALYST COMPOSITION COMPRISING THE SAME, AND A METHOD OF PREPARING AN OLEFINIC POLYMER BY USING THE SAME (AS AMENDED) LG CHEM, LTD. (KR) 2016-06-16 US disclosed
US-20160168281-A1 A METALLOCENE COMPOUND, A CATALYST COMPOSITION COMPRISING THE SAME, AND A METHOD OF PREPARING AN OLEFINIC POLYMER BY USING THE SAME (AS AMENDED) LG CHEM, LTD. (KR) 2016-06-16 US disclosed
US-20160159828-A1 A METALLOCENE COMPOUND, A CATALYST COMPOSITION COMPRISING THE SAME, AND A METHOD OF PREPARING AN OLEFINIC POLYMER BY USING THE SAME (As amended) LG CHEM, LTD. (KR) 2016-06-09 US disclosed
US-20160159828-A1 A METALLOCENE COMPOUND, A CATALYST COMPOSITION COMPRISING THE SAME, AND A METHOD OF PREPARING AN OLEFINIC POLYMER BY USING THE SAME (As amended) LG CHEM, LTD. (KR) 2016-06-09 US disclosed
US-20030148877-A1 Metallocenes and catalysts for olefin-polymerisation BASELL TECHNOLOGY COMPANY BV (NL) 2003-08-07 US disclosed
EP-0952978-B1 METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION BASELL POLYOLEFINE GMBH (DE) 2003-01-22 EP disclosed
US-6451724-B1 BIS(N-METHYL-5,10-DIHYDROINDENO(1,2-B)INDOL-10 -YL)TITANIUM DICHLORIDE BASELL TECHNOLOGY COMPANY BV (NL) 2002-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160168281-A1 A METALLOCENE COMPOUND, A CATALYST COMPOSITION COMPRISING THE SAME, AND A METHOD OF PREPARING AN OLEFINIC POLYMER BY USING THE SAME (AS AMENDED) NOTUM, AGPS, MT-CO1 PGR 2324/4885RORA 3754/4885RORC 4237/4885
US-20030148877-A1 Metallocenes and catalysts for olefin-polymerisation MT-CO1, CPNE4, MT-CO3 PGR 1778/4885RORA 2883/4885RORC 3756/4885
US-20160159828-A1 A METALLOCENE COMPOUND, A CATALYST COMPOSITION COMPRISING THE SAME, AND A METHOD OF PREPARING AN OLEFINIC POLYMER BY USING THE SAME (As amended) NOTUM, AGPS, MT-CO1 PGR 2324/4885RORA 3754/4885RORC 4237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.