Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7121843 | 0.78 | PNMT (0.33) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7119556 | 0.74 | GPR3 (0.36) | — | |
| Hydrochloric Acid SCHEMBL7119329 | 0.73 | GSK3A (0.31) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7124880 | 0.73 | PNMT (0.32) | PNMT | |
| Hydrochloric Acid SCHEMBL7265194 | 0.72 | PNMT (0.35) | PNMTNPC1RAB9A | |
| SCHEMBL7130890 | 0.71 | PNMT (0.32) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7129107 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL5392297 | 0.70 | PNMT (0.32) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5380067 | 0.70 | PNMT (0.33) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7272255 | 0.69 | PNMT (0.36) | PNMTNPC1RAB9AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030148877-A1 | Metallocenes and catalysts for olefin-polymerisation | BASELL TECHNOLOGY COMPANY BV (NL) | 2003-08-07 | — | — | US | disclosed |
| EP-0952978-B1 | METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION | BASELL POLYOLEFINE GMBH (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0952978-A1 | METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION | Montell Technology Company bv (NL) | 1999-11-03 | — | — | EP | disclosed |
| WO-1999024446-A1 | METALLOCENES AND CATALYSTS FOR OLEFIN-POLYMERISATION | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030148877-A1 | Metallocenes and catalysts for olefin-polymerisation | MT-CO1, CPNE4, MT-CO3 | PNMT 259/4885NPC1 2068/4885RAB9A 2768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.