Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131435 | 0.94 | OPRK1 (0.39) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4665354 | 0.89 | DRD2 (0.41) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4665434 | 0.89 | GMNN (0.39) | OPRK1OPRD1OPRM1DRD2DRD4 | |
| SCHEMBL4663618 | 0.89 | GMNN (0.39) | OPRK1OPRD1OPRM1DRD2DRD4 | |
| SCHEMBL4663483 | 0.89 | DRD2 (0.41) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4663376 | 0.88 | TRPA1 (0.39) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4664046 | 0.87 | SMN1; SMN2 (0.48) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4665334 | 0.87 | ALDH1A1 (0.48) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4663731 | 0.84 | OPRM1 (0.36) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 | |
| SCHEMBL4665379 | 0.84 | OPRK1 (0.42) | OPRK1SMN1; SMN2ALDH1A1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368299-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002030870-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | disclosed |