Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133306 | 0.93 | ADAMTS5 (0.50) | ADAMTS5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7136320 | 0.90 | ADAMTS5 (0.54) | ADAMTS5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7137562 | 0.89 | ADAMTS5 (0.52) | ADAMTS5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7134866 | 0.87 | LRRK2 (0.50) | MEN1NPC1RAB9AKMT2APOLB | |
| SCHEMBL7140874 | 0.86 | ADAMTS5 (0.43) | ADAMTS5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7136206 | 0.85 | RET (0.50) | KMT2APOLBNTRK1AKR1B1L3MBTL1 | |
| SCHEMBL7136012 | 0.85 | ADAMTS5 (0.51) | ADAMTS5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7134014 | 0.81 | RET (0.48) | MEN1NPC1RAB9AKMT2APOLB | |
| SCHEMBL7134020 | 0.81 | LRRK2 (0.49) | MAOAMAOBLRRK2RET | |
| SCHEMBL7135594 | 0.81 | MMP13 (0.50) | ADAMTS5MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |