Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130522 | 0.93 | ADAMTS5 (0.51) | ADAMTS5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7134866 | 0.92 | LRRK2 (0.50) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL7136320 | 0.89 | ADAMTS5 (0.54) | ADAMTS5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7137562 | 0.88 | ADAMTS5 (0.52) | ADAMTS5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7132312 | 0.85 | ADAMTS5 (0.50) | ADAMTS5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7140874 | 0.85 | ADAMTS5 (0.43) | ADAMTS5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7136206 | 0.85 | RET (0.50) | KMT2APOLBL3MBTL1LRRK2NTRK1 | |
| SCHEMBL7134020 | 0.80 | LRRK2 (0.49) | LRRK2RETPIM1PIM2MDM2 | |
| SCHEMBL7135594 | 0.80 | MMP13 (0.50) | ADAMTS5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7136994 | 0.79 | MAOA (0.44) | MEN1KMT2ARETPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |