Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078648 | 0.83 | FNTA (0.54) | KMT2AFNTAFNTBMAPTALDH1A1 | |
| SCHEMBL7078057 | 0.83 | HSD11B1 (0.48) | KMT2AFNTAFNTBMAPTHPGD | |
| SCHEMBL7073742 | 0.81 | KMT2A (0.45) | KMT2AFNTAFNTBMAPTHPGD | |
| SCHEMBL7079158 | 0.76 | SMN1; SMN2 (0.43) | KMT2AMAPTHPGDALDH1A1CYP2D6 | |
| SCHEMBL7073376 | 0.75 | ALDH1A1 (0.46) | KMT2AMMP2ALDH1A1HSD11B1 | |
| SCHEMBL7073310 | 0.75 | NFE2L2 (0.49) | KMT2AMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7073308 | 0.75 | NFE2L2 (0.49) | KMT2AMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7079124 | 0.74 | ALDH1A1 (0.45) | KMT2AFNTAFNTBMMP2ALDH1A1 | |
| SCHEMBL7079059 | 0.74 | ALDH1A1 (0.45) | KMT2AFNTAFNTBMAPTMMP2 | |
| SCHEMBL7077837 | 0.71 | ALDH1A1 (0.45) | KMT2AMMP2ALDH1A1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |