Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.64 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.63 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.63 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.62 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13631973 | 0.96 | PGR (0.57) | PGRBRD4ITGB1ITGA2PFKFB3 | |
| SCHEMBL8242878 | 0.92 | PFKFB3 (0.71) | PGRBRD4ITGB1ITGA2PFKFB3 | |
| SCHEMBL13631972 | 0.90 | LMNA (0.59) | PGRBRD4ITGB1ITGA2PFKFB3 | |
| SCHEMBL8278220 | 0.87 | PGR (0.62) | PGRPFKFB3KAT6AMEN1KMT2A | |
| SCHEMBL13631957 | 0.86 | MAP2K4 (0.66) | PFKFB3L3MBTL1MEN1KMT2AHDAC2 | |
| SCHEMBL4183795 | 0.86 | MAP2K4 (0.66) | PGRPFKFB3KAT6AL3MBTL1STING1 | |
| SCHEMBL7805558 | 0.85 | IDH2 (0.61) | PGRPFKFB3KAT6AMEN1KMT2A | |
| SCHEMBL788070 | 0.84 | PFKFB3 (0.83) | PFKFB3KAT6AMEN1KMT2AMAPT | |
| SCHEMBL13631970 | 0.83 | LIMK2 (0.54) | PGRPFKFB3KAT6AL3MBTL1PLAU | |
| SCHEMBL13631971 | 0.82 | PGR (0.54) | PGRPFKFB3KAT6AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120052057-A9 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2012-03-01 | — | — | US | claimed |
| US-20110150859-A1 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2011-06-23 | — | — | US | claimed |
| EP-2140029-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | Biotie Therapies Corp. (FI) | 2010-01-06 | — | — | EP | claimed |
| WO-2008125738-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-23 | — | — | WO | claimed |
| US-20210070866-A1 | Pharmaceutical Composition For Preventing Or Treating Tissue Adhesion Comprising Integrin a2ß1 Inhibitors | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2021-03-11 | — | — | US | disclosed |
| US-20120052057-A9 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2012-03-01 | — | — | US | disclosed |
| US-20110150859-A1 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2011-06-23 | — | — | US | disclosed |
| EP-2140029-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | Biotie Therapies Corp. (FI) | 2010-01-06 | — | — | EP | disclosed |
| US-20090286713-A9 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2009-11-19 | — | — | US | disclosed |
| US-20090286713-A9 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2009-11-19 | — | — | US | disclosed |
| US-20090023735-A1 | Sulphonamide Derivatives | BIOTIE THERAPIES CORP. (FI) | 2009-01-22 | — | — | US | disclosed |
| US-20090023735-A1 | Sulphonamide Derivatives | BIOTIE THERAPIES CORP. (FI) | 2009-01-22 | — | — | US | disclosed |
| WO-2008125738-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-23 | — | — | WO | disclosed |
| US-20080255028-A1 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-16 | — | — | US | disclosed |
| US-20080255028-A1 | Collagen Receptor I-Domain Binding Modulators | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023735-A1 | Sulphonamide Derivatives | HCAR1, ADGRE5, ALK | PGR 1226/4885BRD4 1064/4885ITGB1 19/4885 |
| US-20080255028-A1 | Collagen Receptor I-Domain Binding Modulators | COL14A1, COL2A1, COL1A1 | PGR 848/4885BRD4 713/4885ITGB1 8/4885 |
| US-20090286713-A9 | Collagen Receptor I-Domain Binding Modulators | COL14A1, COL2A1, COL1A1 | PGR 848/4885BRD4 713/4885ITGB1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.