Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434790 | 0.77 | ALDH1A1 (1.00) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL7137220 | 0.77 | ALDH1A1 (0.72) | ALDH1A1HPGDKMT2AMEN1GAA | |
| SCHEMBL4083384 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HPGDKMT2AMEN1GAA | |
| SCHEMBL7137968 | 0.74 | LTA4H (1.00) | LTA4H | |
| SCHEMBL11528650 | 0.74 | LMNA (0.59) | LTA4HL3MBTL1 | |
| SCHEMBL5004504 | 0.73 | ALOX15 (0.70) | ALDH1A1LTA4HKMT2AMEN1L3MBTL1 | |
| SCHEMBL11189472 | 0.72 | ALDH1A1 (0.68) | ALDH1A1GLAHPGDKMT2AMEN1 | |
| SCHEMBL5061453 | 0.72 | CCR1 (0.62) | ALDH1A1KMT2AMEN1GAAL3MBTL1 | |
| SCHEMBL5061456 | 0.72 | CCR1 (0.62) | ALDH1A1KMT2AMEN1GAAL3MBTL1 | |
| SCHEMBL5061450 | 0.72 | CCR1 (0.62) | ALDH1A1KMT2AMEN1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506876-B1 | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. | 2003-01-14 | — | — | US | disclosed |
| EP-1221441-A2 | LTA4 Hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-0786992-A2 | LTA 4? HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5585492-A | USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES WHICH ARE MEDIATED BY LTB4 PRODUCTION, SUCH AS PSORIASIS, ULCERATIVE COLITIS, IRRITABLE BOWEL DISEASE AND ASTHMA | G. D. SEARLE & CO. (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996010999-A2 | LTA4 HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |