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Sugi Predict / Compounds / Sulfamide

Sulfamide

Sulfamide

SCHEMBL7141639

COc1ccc(-c2cc(C(F)F)nn2-c2ccccc2)cc1.NS(N)(=O)=O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 17/20 0.78
▸ PTGS1 P23219 10/20 0.78
▸ ABCB11 O95342 1/20 0.57
▸ ALDH1A1 P00352 1/20 0.57
▸ RPA1 P27694 1/20 0.51
▸ CA1 P00915 1/20 0.50
▸ CA2 P00918 1/20 0.50
▸ CA9 Q16790 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfamide SCHEMBL7145902 0.88 PTGS2 (0.81) PTGS2PTGS1ABCB11ALDH1A1RPA1
SCHEMBL6352119 0.87 PTGS2 (1.00) PTGS2PTGS1ABCB11ALDH1A1CA1
SCHEMBL213308 0.87 PTGS2 (1.00) PTGS2PTGS1ABCB11ALDH1A1CA1
Sulfamide SCHEMBL7143375 0.87 PTGS2 (0.76) PTGS2PTGS1ABCB11ALDH1A1CA1
Sulfamide SCHEMBL7134988 0.84 PTGS2 (0.79) PTGS2PTGS1ABCB11ALDH1A1
Sulfamide SCHEMBL7159984 0.84 PTGS2 (0.76) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL7463018 0.84 PTGS2 (0.81) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8925421 0.84 PTGS2 (0.81) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL7055102 0.84 PTGS2 (0.64) PTGS2PTGS1ABCB11ALDH1A1
SCHEMBL8625458 0.83 PTGS2 (0.67) PTGS2PTGS1ABCB11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0854723-B1 SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR USE IN VETERINARY THERAPIES AS ANTIINFLAMMATORY AGENTS SEARLE & CO (US) 2003-04-23 — — EP claimed