Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CA3 | P07451 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29180133 | 0.92 | PTGS2 (0.67) | PTGS2PTGS1CYP2C9ABCB11ALDH1A1 | |
| Sulfamide SCHEMBL7145902 | 0.91 | PTGS2 (0.81) | PTGS2PTGS1ABCB11ALDH1A1PDPK1 | |
| Sulfamide SCHEMBL7159984 | 0.88 | PTGS2 (0.76) | PTGS2PTGS1ABCB11ALDH1A1PDPK1 | |
| Sulfamide SCHEMBL7141639 | 0.87 | PTGS2 (0.78) | PTGS2PTGS1ABCB11ALDH1A1CA1 | |
| SCHEMBL29180123 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1CYP2C9ALDH1A1ALOX5 | |
| SCHEMBL213150 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9ABCB11ALDH1A1 | |
| SCHEMBL6339195 | 0.86 | PTGS2 (0.90) | PTGS2PTGS1CYP2C9ABCB11ALDH1A1 | |
| SCHEMBL8765170 | 0.84 | PTGS2 (0.70) | PTGS2PTGS1ALOX5 | |
| SCHEMBL8954509 | 0.82 | PTGS2 (0.80) | PTGS2PTGS1CYP2C9ALOX5 | |
| SCHEMBL8165901 | 0.82 | PTGS2 (0.62) | PTGS2PTGS1CYP2C9ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854723-B1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR USE IN VETERINARY THERAPIES AS ANTIINFLAMMATORY AGENTS | SEARLE & CO (US) | 2003-04-23 | — | — | EP | claimed |