SCHEMBL7142147

SCHEMBL7142147

O=C(O)c1ccc2c3c(ncnc13)-c1ccccc1C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 1.00
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
KDM4E B2RXH2 4/20 1.00
HSP90AA1 P07900 1/20 1.00
HSP90AB1 P08238 1/20 1.00
HPGD P15428 1/20 1.00
HTT P42858 1/20 1.00
ALDH1A1 P00352 5/20 0.46
MAPK1 P28482 5/20 0.46
LMNA P02545 3/20 0.46
POLB P06746 2/20 0.46
THRB P10828 1/20 0.46
RECQL P46063 1/20 0.46
MAOA P21397 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MMP14 P50281 1/20 0.43
TTR P02766 2/20 0.41
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30919368 1.00 MAPT (1.00) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL8445003 0.87 MAPT (0.78) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL7820954 0.84 KMT2A (0.71) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL29356341 0.78 MAPT (0.63) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL16323481 0.78 MAPT (0.63) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL20869701 0.75 MAPT (0.60) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL14200808 0.72 MAPT (0.57) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL13196135 0.72 KDM4E (0.56) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL460367 0.70 MAOA (0.56) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL68338 0.65 TTR (0.64) MAPTMEN1KMT2AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11975032-B2 Medicament for liver regeneration and for treatment of liver failure MEDIZINISCHE HOCHSCHULE HANNOVER (DE) 2024-05-07 US disclosed
US-20190099453-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) 2019-04-04 US disclosed
US-20190091265-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) 2019-03-28 US disclosed
US-10188682-B2 Medicament for liver regeneration and for treatment of liver failure Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2019-01-29 US disclosed
EP-3192870-B1 CULTIVATED HEPATOCYTE FOR BLOOD PURIFICATION HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) 2018-10-17 EP disclosed
EP-3192870-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2017-07-19 EP disclosed
EP-2694652-B1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2017-02-01 EP disclosed
US-9273012-B2 Facile preparation of 4-substituted quinazolines and related heterocycles UNIVERSITY OF HOUSTON SYSTEM (US) 2016-03-01 US disclosed
US-20160022742-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) 2016-01-28 US disclosed
US-20160022742-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) 2016-01-28 US disclosed
US-20140141510-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE MEDIZINISCHE HOCHSCHULE HANNOVER (DE) 2014-05-22 US disclosed
US-20140141510-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE MEDIZINISCHE HOCHSCHULE HANNOVER (DE) 2014-05-22 US disclosed
EP-2694652-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2014-02-12 EP disclosed
US-20120283436-A1 FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES THE UNIVERSITY OF HOUSTON (US) 2012-11-08 US disclosed
WO-2012136859-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2012-10-11 WO disclosed
EP-0483249-B1 METHOD OF TRANSCRIPTIONALLY MODULATING GENE EXPRESSION AND OF DISCOVERING CHEMICALS CAPABLE OF FUNCTIONING AS GENE EXPRESSION MODULATORS OSI PHARM INC (US) 2003-04-23 EP disclosed
US-6376175-B1 CONTACTING CELL WHICH IS CAPABLE OF EXPRESSING GENE WITH AMOUNT OF MOLECULE EFFECTIVE TO TRANSCRIPTIONALLY MODULATE EXPRESSION OF GENE AND THEREBY AFFECT LEVEL OF PROTEIN ENCODED BY GENE WHICH IS EXPRESSED BY CELL OSI PHARMACEUTICALS, INC. 2002-04-23 US disclosed
US-5861398-A Benzoperimidine-carboxylic acids and derivatives thereof ALANEX CORPORATION (US) 1999-01-19 US disclosed
WO-1998008821-A1 BENZOPERIMIDINE-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF AGOURON ACQUISITION CORP. (US) 1998-03-05 WO disclosed
US-5665543-A Method of discovering chemicals capable of functioning as gene expression modulators ONCOGENE SCIENCE, INC. (US) 1997-09-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160022742-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE PYGL, HNF4A, ATF1 MAPT 4517/4885MEN1 3939/4885KMT2A 2105/4885
US-20140141510-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE PYGL, HNF4A, ATF1 MAPT 4517/4885MEN1 3939/4885KMT2A 2105/4885
US-20190091265-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE PYGL, HNF4A, ATF1 MAPT 4517/4885MEN1 3939/4885KMT2A 2105/4885
US-10188682-B2 Medicament for liver regeneration and for treatment of liver failure PYGL, HNF4A, ATF1 MAPT 4517/4885MEN1 3939/4885KMT2A 2105/4885
US-20190099453-A1 MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE PYGL, HNF4A, ATF1 MAPT 4517/4885MEN1 3939/4885KMT2A 2105/4885
US-11975032-B2 Medicament for liver regeneration and for treatment of liver failure PYGL, HNF4A, ATF1 MAPT 4517/4885MEN1 3939/4885KMT2A 2105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.