SCHEMBL460367

SCHEMBL460367

O=C1c2ccccc2-c2ncnc3cccc1c23

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.56
MAPT P10636 5/20 0.54
KMT2A Q03164 5/20 0.54
MEN1 O00255 4/20 0.54
KDM4E B2RXH2 2/20 0.54
HSP90AA1 P07900 1/20 0.54
HSP90AB1 P08238 1/20 0.54
HPGD P15428 1/20 0.54
HTT P42858 1/20 0.54
NPC1 O15118 3/20 0.47
ALDH1A1 P00352 3/20 0.47
EIF2AK2 P19525 2/20 0.47
APEX1 P27695 2/20 0.47
MAPK12 P53778 2/20 0.47
CYP3A4 P08684 2/20 0.47
PABPC1 P11940 2/20 0.47
CASP1 P29466 2/20 0.47
CASP7 P55210 2/20 0.47
MAPK1 P28482 2/20 0.47
CDC7 O00311 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6921257 0.78 MAOA (0.42) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL1311132 0.76 MAPT (0.53) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL11964703 0.76 ADORA2A (0.53) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL458586 0.73 PABPC1 (0.55) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL29827450 0.73 PABPC1 (0.55) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL20256150 0.72 MAPT (0.50) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL7534095 0.72 MAPT (0.58) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL1969983 0.71 MAOA (1.00) MAOAALDH1A1CYP3A4PABPC1CASP1
SCHEMBL20256312 0.71 KDM4E (0.47) MAOAMAPTKMT2AMEN1KDM4E
SCHEMBL20869701 0.71 MAPT (0.60) MAOAMAPTKMT2AMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060147737-A1 Reactive colorant compounds and polymeric materials copolymerized therewith EASTMAN CHEMICAL COMPANY 2006-07-06 US claimed
US-6776930-B2 POLYMER BONDED TO DYE EASTMAN KODAK COMPANY 2004-08-17 US claimed
EP-0747036-B1 A method of coloring hair with, and hair coloring compositions comprising, sulfo-containing water dispersible colored polymers CLAIROL INC (US) 2003-05-07 EP claimed
US-20010023938-A1 Polymer bonded to dye ALLEN MAX (US) 2001-09-27 US claimed
US-6197223-B1 REACTING DIACIDIC MONOMER HAVING FORMULA H--A--H, COMPRISING 1 TO 100 MOLE % OF LIGHT-ABSORBING MONOMER HAVING A LIGHT ABSORPTION MAXIMUM BETWEEN 300 NM AND 1200 NM AND 99-0 MOLE % OF A NON-LIGHT ABSORBING MONOMER WITH ORGANIC COMPOUND EASTMAN CHEMICAL COMPANY 2001-03-06 US claimed
EP-0948570-A1 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1999-10-13 EP claimed
EP-0869765-A1 AQUEOUS NAIL COATING COMPOSITION CONTAINING COPOLYMERIZED COLORANTS EASTMAN CHEMICAL COMPANY (US) 1998-10-14 EP claimed
WO-1998023690-A1 METHOD FOR PREPARING LIGHT-ABSORBING POLYMERIC COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1998-06-04 WO claimed
WO-1997024102-A1 AQUEOUS NAIL COATING COMPOSITION CONTAINING COPOLYMERIZED COLORANTS EASTMAN CHEMICAL COMPANY (US) 1997-07-10 WO claimed
EP-0747036-A2 A method of coloring hair with, and hair coloring compositions comprising, sulfo-containing water dispersible colored polymers Bristol-Myers Squibb Company (US) 1996-12-11 EP claimed
EP-0445926-B1 Organic materials having sulfonamido linked poly(oxyalkylene) moieties and their preparation MILLIKEN RES CORP (US) 1996-08-21 EP claimed
EP-0400038-A1 WATER-DISSIPATABLE POLYESTER AND POLYESTER-AMIDES CONTAINING COPOLYMERIZED COLORANTS EASTMAN CHEMICAL COMPANY (US) 1990-12-05 EP claimed
WO-1989007118-A1 WATER-DISSIPATABLE POLYESTER AND POLYESTER-AMIDES CONTAINING COPOLYMERIZED COLORANTS EASTMAN KODAK COMPANY (US) 1989-08-10 WO claimed
US-4804719-A PRINTING INKS; COATINGS; HEAT AND COLD RESISTANCE EASTMAN KODAK COMPANY (US) 1989-02-14 US claimed
US-20240239730-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-07-18 US disclosed
EP-4389765-A2 METHODS OF PERMEABILIZING THE BLOOD BRAIN BARRIER University of Southern California (US) 2024-06-26 EP disclosed
US-11970436-B2 Pharmaceutical compositions comprising monoterpenes UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-04-30 US disclosed
EP-0400038-A1 WATER-DISSIPATABLE POLYESTER AND POLYESTER-AMIDES CONTAINING COPOLYMERIZED COLORANTS EASTMAN CHEMICAL COMPANY (US) 1990-12-05 EP disclosed
WO-1989007118-A1 WATER-DISSIPATABLE POLYESTER AND POLYESTER-AMIDES CONTAINING COPOLYMERIZED COLORANTS EASTMAN KODAK COMPANY (US) 1989-08-10 WO disclosed
US-4804719-A PRINTING INKS; COATINGS; HEAT AND COLD RESISTANCE EASTMAN KODAK COMPANY (US) 1989-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239730-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES SQLE, DHPS, GGPS1 MAOA 3081/4885MAPT 1232/4885KMT2A 4026/4885
US-11970436-B2 Pharmaceutical compositions comprising monoterpenes SQLE, DHPS, GGPS1 MAOA 3081/4885MAPT 1232/4885KMT2A 4026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.