Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142622 | 0.86 | MAPT (0.52) | ALDH1A1KDM4EMAPTKMT2ATHRB | |
| SCHEMBL12169159 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL12169059 | 0.78 | ADORA2B (0.47) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL3788207 | 0.75 | HSD17B10 (0.49) | ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL18701258 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTKMT2ALMNA | |
| SCHEMBL10854437 | 0.73 | ADORA2B (0.45) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL10838564 | 0.73 | KDM4E (0.48) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL4568008 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL23665412 | 0.70 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL12169158 | 0.70 | ACHE (0.50) | ALDH1A1KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | claimed |
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |