Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
| ▸ | PDE6G | P18545 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE6B | P35913 | 1/20 | 0.38 |
| ▸ | PDE6C | P51160 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045163 | 0.85 | JAK2 (0.47) | JAK2PDE10ANUDT1PDE4DHSP90AB1 | |
| SCHEMBL7148123 | 0.85 | NUDT1 (0.55) | JAK2PDE10ANUDT1PDE4DHSP90AB1 | |
| SCHEMBL2250839 | 0.82 | PDE4D (0.64) | JAK2PDE10ANUDT1PDE4DHSP90AB1 | |
| SCHEMBL7144538 | 0.78 | PDE4D (0.49) | PDE10APDE4DHSP90AB1MAPT | |
| SCHEMBL7145674 | 0.76 | PDE10A (0.50) | PDE10APDE4DHSP90AB1 | |
| SCHEMBL7043078 | 0.75 | JAK1 (0.60) | PDE10APDE4DHSP90AB1MAPT | |
| SCHEMBL2257907 | 0.74 | MAPT (0.49) | JAK2PDE10APDE4DHSP90AB1MAPT | |
| SCHEMBL7146898 | 0.74 | KDM4E (0.51) | PDE10APDE4D | |
| SCHEMBL7043841 | 0.74 | MAPT (0.51) | PDE10APDE4DHSP90AB1MAPT | |
| SCHEMBL4066707 | 0.73 | PDE10A (0.45) | JAK2PDE10APDE4DHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |