Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144538 | 0.85 | PDE4D (0.49) | PDE4DJAK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL7043078 | 0.85 | JAK1 (0.60) | PDE4DJAK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL7146898 | 0.84 | KDM4E (0.51) | PDE4DJAK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL2257907 | 0.84 | MAPT (0.49) | PDE4DJAK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL2250839 | 0.83 | PDE4D (0.64) | PDE4DJAK1PDE10AKDM4EHSP90AB1 | |
| SCHEMBL6875680 | 0.76 | PDE10A (0.44) | PDE4DJAK1PDE10ATUBB4ATUBB | |
| SCHEMBL7043841 | 0.75 | MAPT (0.51) | PDE4DJAK1PDE10AKDM4EALDH1A1 | |
| SCHEMBL7145674 | 0.75 | PDE10A (0.50) | PDE4DJAK1PDE10AHPGDHSP90AB1 | |
| SCHEMBL7146570 | 0.74 | PDE4D (0.48) | PDE4DJAK1PDE10ATUBB4ATUBB | |
| SCHEMBL6876513 | 0.74 | PDE4D (0.48) | PDE4DJAK1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |