Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.36 |
| ▸ | IL6 | P05231 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.34 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206213 | 0.89 | CXCR4 (0.46) | CXCR4HTR1AMEN1LMNAKMT2A | |
| SCHEMBL10484107 | 0.76 | NFKB1 (0.44) | CXCR4MEN1LMNAKMT2AS1PR3 | |
| SCHEMBL10862698 | 0.76 | HRH3 (0.48) | CXCR4S1PR3POLBHRH3CYP1A2 | |
| SCHEMBL17409833 | 0.72 | TLR7 (0.46) | CXCR4MEN1LMNAKMT2AIL6 | |
| SCHEMBL10483936 | 0.71 | HRH3 (0.46) | MEN1KMT2AIL6TLR7HRH3 | |
| SCHEMBL4618374 | 0.70 | NOS3 (0.39) | CXCR4HTR1A | |
| Tromethamine SCHEMBL6204282 | 0.70 | TRPV1 (0.35) | LMNARAB9A | |
| SCHEMBL7143514 | 0.70 | KMT2A (0.42) | CXCR4HTR1AMEN1LMNAKMT2A | |
| SCHEMBL7662084 | 0.69 | CXCR4 (0.52) | CXCR4MEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL19580586 | 0.68 | HRH3 (0.47) | CXCR4MEN1LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341893-A1 | ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002048307-A1 | ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2002-06-20 | — | — | WO | disclosed |