Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5968788 | 0.89 | HTR5A (0.37) | TRPV1ADORA2AHTR5AALDH1A1KDM4E | |
| Tromethamine SCHEMBL6204530 | 0.84 | ADORA2A (0.37) | ADORA2ASLC40A1ALDH1A1 | |
| SCHEMBL4620705 | 0.71 | SCN8A (0.42) | ADORA2AALDH1A1CHRM2 | |
| SCHEMBL6204283 | 0.70 | HTR5A (0.37) | TRPV1ADORA2ASLC40A1HTR5AALDH1A1 | |
| Tromethamine SCHEMBL7143511 | 0.70 | CXCR4 (0.39) | LMNARAB9A | |
| SCHEMBL20170890 | 0.69 | SLC6A2 (0.40) | ADORA2ASLC40A1ALDH1A1KDM4ELMNA | |
| SCHEMBL5115647 | 0.69 | L3MBTL1 (0.55) | ADORA2AALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL17778287 | 0.69 | DPP4 (0.40) | ADORA2AALDH1A1KDM4ELMNAL3MBTL1 | |
| SCHEMBL10483955 | 0.68 | CHRM2 (0.40) | SLC40A1HTR5AKDM4ECHRM2 | |
| Hydrochloric Acid SCHEMBL11702829 | 0.67 | POLB (0.38) | ALDH1A1KDM4ERAB9ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506277-A1 | ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097780-A1 | ENZYMATIC DETERGENT COMPOSITIONS | UNILEVER N.V. (NL) | 2003-11-27 | — | — | WO | disclosed |