Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.37 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7143554 | 1.00 | LMNA (0.41) | LMNASMN1; SMN2GAAKDM4EHTT | |
| Water SCHEMBL7140424 | 0.79 | PTAFR (0.40) | KCNH2MAPK1PTAFRCCR3DRD2 | |
| SCHEMBL7140680 | 0.76 | PTAFR (0.40) | KCNH2PTAFRALDH1A1DRD2HRH1 | |
| SCHEMBL7136262 | 0.75 | PTAFR (0.43) | HTTTSHRKCNH2PTAFRALDH1A1 | |
| SCHEMBL7141837 | 0.75 | HRH1 (0.50) | LMNASMN1; SMN2KDM4EHTTTSHR | |
| Oxalic Acid SCHEMBL7138856 | 0.73 | HTR5A (0.49) | SMN1; SMN2KDM4ENPC1ALDH1A1HTR1A | |
| SCHEMBL7139726 | 0.73 | HRH1 (0.38) | HTTKCNH2PTAFRDRD2SLC6A2 | |
| SCHEMBL7141253 | 0.72 | PTAFR (0.38) | LMNAKCNH2PTAFRMEN1KMT2A | |
| SCHEMBL7166986 | 0.71 | HRH1 (0.47) | TSHRKCNH2MEN1KMT2ACACNA1G | |
| Water SCHEMBL9288075 | 0.70 | LMNA (0.45) | LMNAKCNH2CYP2D6MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675887-B1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-02 | — | — | EP | disclosed |