Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | APEX1 | P27695 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28329948 | 0.80 | ALOX15 (0.46) | ALOX15TDP1TSHRALDH1A1KDM4E | |
| SCHEMBL8693513 | 0.78 | MAOA (0.53) | ALOX15TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL855919 | 0.76 | TSHR (0.46) | ALOX15TDP1TSHRALDH1A1MEN1 | |
| SCHEMBL29462451 | 0.76 | TSHR (0.46) | ALOX15TDP1TSHRALDH1A1MEN1 | |
| SCHEMBL7139576 | 0.75 | DBH (0.45) | ALOX15TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9751985 | 0.73 | ELANE (0.55) | ALOX15TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL20496850 | 0.73 | ALOX15 (0.39) | ALOX15TDP1TSHRALDH1A1KDM4E | |
| SCHEMBL28098187 | 0.72 | ADORA3 (0.42) | ALOX15TDP1ALDH1A1HPGDMAOA | |
| SCHEMBL7142220 | 0.71 | HDAC4 (0.50) | ALOX15TDP1TSHRALDH1A1KDM4E | |
| SCHEMBL29688935 | 0.70 | TSHR (0.52) | ALOX15TDP1TSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828483-B1 | USE OF TROPOLONE DERIVATIVES AS INHIBITORS OF THE ENZYME INOSITOL MONOPHOSPHATASE | LEPETIT SPA (IT) | 2003-01-29 | — | — | EP | disclosed |
| US-5990160-A | Use of tropolone derivatives as inhibitors of the enzyme inositol monophosphatase | GRUPPO LEPETIT, SPA (IT) | 1999-11-23 | — | — | US | disclosed |
| EP-0828483-A1 | USE OF TROPOLONE DERIVATIVES AS INHIBITORS OF THE ENZYME INOSITOL MONOPHOSPHATASE | GRUPPO LEPETIT S.p.A. (IT) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037197-A1 | USE OF TROPOLONE DERIVATIVES AS INHIBITORS OF THE ENZYME INOSITOL MONOPHOSPHATASE | GRUPPO LEPETIT S.P.A. (IT) | 1996-11-28 | — | — | WO | disclosed |