Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | GOT1 | P17174 | 5/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5705067 | 0.83 | POLB (0.44) | MAPTGAA | |
| SCHEMBL2857040 | 0.76 | AKR1C3 (0.64) | MAPTGAAGRM5AKR1C3DRD2 | |
| SCHEMBL27237946 | 0.75 | DRD2 (0.60) | AKR1C3TRPV1DRD2DRD4DRD3 | |
| SCHEMBL2228008 | 0.73 | GOT1 (0.70) | MAPTGAARECQLGOT1DRD2 | |
| SCHEMBL27237926 | 0.73 | AKR1C3 (0.49) | MAPTGAAGRM5AKR1C3DRD2 | |
| SCHEMBL27237912 | 0.73 | ALDH1A1 (0.55) | MAPTGAAAKR1C3DRD2 | |
| SCHEMBL2228708 | 0.71 | DRD2 (0.67) | DRD2 | |
| SCHEMBL20139276 | 0.71 | AKR1C3 (0.57) | MAPTGAAGRM5AKR1C3DRD2 | |
| SCHEMBL27237942 | 0.71 | KMT2A (0.50) | MAPTGAAAKR1C3TRPV1GFER | |
| SCHEMBL3924263 | 0.70 | AKR1C3 (0.47) | MAPTGAAGRM5AKR1C3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335722-A2 | COMPOUNDS USEFUL IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002041889-A2 | INDOLSULFONYL COMPOUNDS USEFUL IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-05-30 | — | — | WO | disclosed |