SCHEMBL7699102

SCHEMBL7699102

Cc1nc2sccn2c(=O)c1CCN1CCC(c2csc3ccccc23)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 14/20 0.54
SLC6A4 P31645 2/20 0.54
HTR1A P08908 14/20 0.53
HTR2A P28223 13/20 0.53
CYP2D6 P10635 3/20 0.53
MAPT P10636 3/20 0.53
TSHR P16473 3/20 0.53
ALDH1A1 P00352 2/20 0.53
LMNA P02545 2/20 0.53
TP53 P04637 2/20 0.53
CYP2C9 P11712 2/20 0.53
ALOX15 P16050 2/20 0.53
DGKA P23743 2/20 0.53
HSD17B10 Q99714 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
KDM4E B2RXH2 2/20 0.53
CYP2C19 P33261 1/20 0.53
HTR2C P28335 5/20 0.52
ADRA1A P35348 5/20 0.52
HRH1 P35367 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10944718 0.85 ALDH1A1 (0.51) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL7699928 0.85 ADRA1A (0.54) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL10922663 0.81 CYP2D6 (0.51) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL7702842 0.79 DRD2 (0.79) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL9276925 0.78 DRD2 (0.56) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL7147314 0.77 CYP2D6 (0.54) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL10924461 0.77 SLC6A4 (0.55) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL10923035 0.77 HTR1A (0.47) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL7699932 0.77 DRD2 (0.55) DRD2SLC6A4HTR1AHTR2ACYP2D6
SCHEMBL12786167 0.77 ALDH1A1 (0.56) DRD2SLC6A4HTR1AHTR2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6348457-B1 ANTAGONIZING RESERPINE IN MAMMALS JANSSEN PHARMACEUTICA N.V. (BE) 2002-02-19 US disclosed
EP-0672043-B1 NOVEL 4-(3-BENZOFURANYL)PIPERIDINYL AND 4-(3-BENZOTHIENYL)PIPERIDINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM JANSSEN PHARMACEUTICA NV (BE) 2001-05-30 EP disclosed