Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584513 | 0.84 | KMT2A (0.56) | CES2CES1PTPN1KMT2AALDH1A1 | |
| SCHEMBL28201534 | 0.82 | KMT2A (0.54) | CES2CES1PTPN1KMT2AALDH1A1 | |
| SCHEMBL43960 | 0.76 | — | — | |
| SCHEMBL27777913 | 0.76 | CES2 (0.65) | CES2CES1PTPN1KMT2AALDH1A1 | |
| Acetic Acid Methyl Ester SCHEMBL27507525 | 0.74 | CES2 (0.57) | CES2CES1PTPN1KMT2AALDH1A1 | |
| SCHEMBL896787 | 0.74 | CES2 (0.62) | CES2CES1PTPN1KMT2AALDH1A1 | |
| Methane SCHEMBL27898477 | 0.74 | — | — | |
| SCHEMBL27514702 | 0.74 | CES2 (0.62) | CES2CES1PTPN1KMT2AALDH1A1 | |
| Water SCHEMBL27897236 | 0.74 | — | — | |
| SCHEMBL27670963 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645960-B1 | Antiprotozoa agents for animal or human infections | GLAXO WELLCOME S.A. (ES) | 2003-11-11 | — | — | US | disclosed |
| US-6436930-B1 | FOR TREATMENT OF INFECTIONS BY CANDIDA ALBICANS | BRISTOL-MYERS SQUIBB COMPANY | 2002-08-20 | — | — | US | disclosed |
| EP-1228049-A1 | ANTIFUNGAL SORDARICIN DERIVATIVES | Glaxo Wellcome S.A. (ES) | 2002-08-07 | — | — | EP | disclosed |
| US-6410528-B1 | FUNGICIDES, ANTIPROTOZOA AGENT | GLAXO WELLCOME S.A. (ES) | 2002-06-25 | — | — | US | disclosed |
| US-20020035073-A1 | Novel thio derivatives of sordarin as antifungal agents | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-21 | — | — | US | disclosed |
| WO-2002022567-A1 | NOVEL THIO DERIVATIVES OF SORDARIN AS ANTIFUNGAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-21 | — | — | WO | disclosed |
| WO-2001034583-A1 | ANTIFUNGAL SORDARICIN DERIVATIVES | GLAXO WELLCOME SA (ES) | 2001-05-17 | — | — | WO | disclosed |
| EP-1077959-A1 | MORPHOLINO ETHERS | Glaxo Wellcome S.A. (ES) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058512-A1 | MORPHOLINO ETHERS | GLAXO WELLCOME S.A. (ES) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035073-A1 | Novel thio derivatives of sordarin as antifungal agents | SORD, SFXN1, TST | CES2 3899/4885CES1 3025/4885PTPN1 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.