Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6787629 | 0.80 | LIPE (0.41) | MMP13ADAMTS5MMP2MMP12ADAMTS4 | |
| SCHEMBL942365 | 0.76 | MMP13 (0.45) | MMP13ADAMTS5MMP2MMP12ADAMTS4 | |
| SCHEMBL6787131 | 0.76 | CYP3A4 (0.41) | LIPESCN9AP2RX3 | |
| SCHEMBL1108546 | 0.67 | PTGS1 (0.41) | MMP13ADAMTS5MMP2MMP12ADAMTS4 | |
| SCHEMBL1108576 | 0.67 | PTGS1 (0.41) | MMP13ADAMTS5MMP2MMP12ADAMTS4 | |
| SCHEMBL17487850 | 0.65 | ADRB2 (0.52) | LIPESCN9ALTA4HHRH3FPR2 | |
| SCHEMBL6878178 | 0.65 | MMP13 (0.58) | MMP13ADAMTS5MMP2MMP12ADAMTS4 | |
| SCHEMBL6791426 | 0.65 | ACACB (0.46) | LIPESCN9ALTA4H | |
| SCHEMBL8683717 | 0.64 | LIPE (0.54) | SMN1; SMN2NPSR1LIPESCN9ALTA4H | |
| SCHEMBL8684262 | 0.63 | LIPE (0.51) | SMN1; SMN2LIPESCN9ALTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |