Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.58 |
| ▸ | MMP2 | P08253 | 4/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.58 |
| ▸ | MMP12 | P39900 | 3/20 | 0.58 |
| ▸ | MMP3 | P08254 | 2/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12416702 | 0.87 | ALDH1A1 (0.48) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL6876082 | 0.83 | MMP13 (0.47) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL12378824 | 0.81 | SMN1; SMN2 (0.48) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL6794277 | 0.81 | ALDH1A1 (0.51) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL1108471 | 0.80 | ALDH1A1 (0.52) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL1108470 | 0.80 | MMP2 (0.46) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL6878332 | 0.79 | PGR (0.49) | MMP13MMP2MMP3SMN1; SMN2NPSR1 | |
| SCHEMBL6840055 | 0.78 | SMN1; SMN2 (0.40) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL12378666 | 0.76 | ALDH1A1 (0.46) | MMP13MMP2ADAMTS5MMP12MMP3 | |
| SCHEMBL6874389 | 0.74 | MMP13 (0.49) | MMP13MMP2ADAMTS5MMP12MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040106659-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | US | disclosed |
| EP-1370534-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074748-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106659-A1 | Metalloproteinase inhibitors | MMP9, TIMP3, MMP11 | MMP13 11/4885MMP2 9/4885ADAMTS5 26/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | MMP13 19/4885MMP2 11/4885ADAMTS5 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.