Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149801 | 0.88 | PIP4K2A (0.44) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL7149804 | 0.83 | LMNA (0.39) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL7166273 | 0.75 | SRC (0.53) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL7202389 | 0.72 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL6223729 | 0.70 | ALDH1A1 (0.67) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL16618012 | 0.70 | RIOK3 (0.54) | ALDH1A1KDM4EHPGDCHEK1SRC | |
| SCHEMBL3224685 | 0.70 | SRC (0.74) | SRC | |
| SCHEMBL28750720 | 0.67 | ADORA2A (0.51) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL7913439 | 0.66 | KDM4E (0.60) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL27576302 | 0.65 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |