Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 13/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16493681 | 0.84 | RIPK1 (0.45) | RIPK1CCNE1CDK2IGF1R | |
| SCHEMBL1777558 | 0.80 | RIPK1 (0.50) | RIPK1SYK | |
| SCHEMBL7151357 | 0.79 | RIPK1 (0.57) | RIPK1IGF1R | |
| SCHEMBL1748617 | 0.76 | RIPK1 (0.57) | RIPK1CCNE1CDK2 | |
| SCHEMBL27714279 | 0.72 | RIPK1 (0.55) | RIPK1CCNE1CDK2IGF1R | |
| SCHEMBL26174487 | 0.72 | RIPK1 (0.57) | RIPK1CCNE1CDK2 | |
| SCHEMBL12606369 | 0.68 | RIPK1 (0.50) | RIPK1CCNE1CDK2 | |
| SCHEMBL4781130 | 0.68 | GSK3B (0.47) | IGF1R | |
| SCHEMBL12606292 | 0.67 | SYK (0.61) | RIPK1CCNE1CDK2SYKIGF1R | |
| SCHEMBL25253727 | 0.67 | F7 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397360-A1 | AZAINDOLES | Aventis Pharma Limited (GB) | 2004-03-17 | — | — | EP | claimed |
| WO-2003000688-A1 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2003-01-03 | — | — | WO | claimed |