Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748617 | 0.84 | RIPK1 (0.57) | RIPK1DYRK1ACCNE1CDK2 | |
| SCHEMBL7151357 | 0.80 | RIPK1 (0.57) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL26174487 | 0.79 | RIPK1 (0.57) | RIPK1CLK2DYRK1ACCNE1CDK2 | |
| SCHEMBL12606369 | 0.77 | RIPK1 (0.50) | RIPK1CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL1777558 | 0.76 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL16493681 | 0.75 | RIPK1 (0.45) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL4780727 | 0.74 | RIPK1 (0.59) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL18426993 | 0.73 | ITK (0.76) | CCNB2CDK1CCNB1CCNB3CLK2 | |
| SCHEMBL7168363 | 0.72 | RIPK1 (0.46) | RIPK1IGF1RCCNE1CDK2 | |
| SCHEMBL15436394 | 0.72 | CDC7 (0.50) | CLK2DYRK1AITKCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101052642-A | Novel bis-azaindole derivatives, their preparation and their pharmaceutical use as kinase inhibitors | AVENTIS PHARMA SA (FR) | 2007-10-10 | — | — | CN | disclosed |