Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | PDE5A | O76074 | 3/20 | 0.51 |
| ▸ | GBA1 | P04062 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.49 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713670 | 0.91 | SLC6A7 (0.54) | SLC6A7MEN1KMT2APDE5AGBA1 | |
| SCHEMBL713649 | 0.87 | SLC6A7 (0.52) | SLC6A7MEN1KMT2APDE5ALMNA | |
| SCHEMBL715005 | 0.80 | ABCG2 (0.53) | SLC6A7MEN1KMT2APDE5ATSHR | |
| SCHEMBL3588194 | 0.80 | SLC6A7 (0.74) | SLC6A7MEN1KMT2ALMNATSHR | |
| SCHEMBL713528 | 0.79 | KIT (0.56) | SLC6A7PDE5ALMNATSHRMAPK10 | |
| SCHEMBL3640288 | 0.78 | PDE5A (0.68) | SLC6A7KMT2APDE5ALMNAHPGD | |
| SCHEMBL3645095 | 0.78 | CTNNB1 (0.68) | MEN1KMT2APDE5ALMNAMAPT | |
| SCHEMBL715211 | 0.77 | RAB9A (0.55) | SLC6A7MEN1KMT2ALMNAHPGD | |
| SCHEMBL715268 | 0.75 | LMNA (0.61) | MEN1KMT2AGBA1LMNATSHR | |
| SCHEMBL713933 | 0.75 | MEN1 (0.55) | SLC6A7MEN1KMT2APDE5ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609672-B2 | Piperazinylpyrimidine analogues as protein kinase inhibitors | UNIVERSITY OF THE PACIFIC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2012027495-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | DCK, PAK5, CDK2 | SLC6A7 1983/4885MEN1 3873/4885KMT2A 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.