Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7151773 | 0.94 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7149249 | 0.93 | ALDH1A1 (0.53) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7153222 | 0.89 | PDK1 (0.53) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7154367 | 0.89 | L3MBTL1 (0.55) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7151736 | 0.89 | ALDH1A1 (0.56) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7150889 | 0.88 | ALDH1A1 (0.62) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7148130 | 0.86 | MAPT (0.46) | ALDH1A1HSD17B10MAPTSMN1; SMN2LMNA | |
| SCHEMBL7149325 | 0.84 | MAPT (0.53) | MAPTSMN1; SMN2LMNAPOLBL3MBTL1 | |
| SCHEMBL7150052 | 0.83 | PDK1 (0.51) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL7149622 | 0.83 | ALDH1A1 (0.59) | ALDH1A1HSD17B10MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642263-B2 | Antitumor agents, sulfided benzothiazole derivative containing sulfonamide | ICONIX PHARMACEUTICALS INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030176474-A1 | Modulators of Rho C activity | ICONIX BIOSCIENCES, INC. | 2003-09-18 | — | — | US | disclosed |
| WO-2003043577-A2 | MODULATORS OF RHO C ACTIVITY | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176474-A1 | Modulators of Rho C activity | RHOC, ARHGDIA, ROCK1 | ALDH1A1 2919/4885HSD17B10 2088/4885MAPT 3839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.