Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 13/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147065 | 0.94 | LMNA (0.46) | LMNAALDH1A1HTTALOX15MAPK1 | |
| SCHEMBL7153984 | 0.94 | LMNA (0.46) | LMNAALDH1A1HTTALOX15MAPK1 | |
| SCHEMBL7151080 | 0.90 | LMNA (0.49) | LMNAALDH1A1HTTALOX15MAPK1 | |
| SCHEMBL7146699 | 0.90 | ALDH1A1 (0.47) | LMNAALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7151736 | 0.89 | ALDH1A1 (0.56) | LMNAALDH1A1HTTMAPK1MAPT | |
| SCHEMBL7148130 | 0.89 | MAPT (0.46) | LMNAALDH1A1HTTALOX15MAPK1 | |
| SCHEMBL7151273 | 0.87 | MAPT (0.52) | LMNAALDH1A1HTTMAPK1MAPT | |
| SCHEMBL7153219 | 0.86 | PDK1 (0.47) | LMNAALDH1A1HTTMAPK1MAPT | |
| SCHEMBL7147361 | 0.85 | ALDH1A1 (0.47) | LMNAALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7146167 | 0.84 | ALDH1A1 (0.43) | LMNAALDH1A1HTTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642263-B2 | Antitumor agents, sulfided benzothiazole derivative containing sulfonamide | ICONIX PHARMACEUTICALS INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030176474-A1 | Modulators of Rho C activity | ICONIX BIOSCIENCES, INC. | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176474-A1 | Modulators of Rho C activity | RHOC, ARHGDIA, ROCK1 | LMNA 1481/4885ALDH1A1 2919/4885HTT 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.