Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | RXRA | P19793 | 7/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7155610 | 0.84 | POLB (0.48) | KCNH2RXRAGRIN1GRIN2BDHFR | |
| SCHEMBL7154140 | 0.83 | KCNH2 (0.47) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL8139457 | 0.73 | KCNH2 (0.43) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL28266377 | 0.71 | RXRA (0.47) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL28266397 | 0.70 | PIM1 (0.44) | KCNH2RXRAGRIN1GRIN2BNPY5R | |
| SCHEMBL1344378 | 0.69 | KCNH2 (0.40) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL3147185 | 0.68 | GPR3 (0.50) | PIM1 | |
| SCHEMBL31465861 | 0.68 | PDE10A (0.48) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL8425506 | 0.68 | RXRA (0.39) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL12245 | 0.67 | ACHE (0.56) | KCNH2GRM5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |