Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | RAB9A | P51151 | 5/20 | 0.76 |
| ▸ | NPC1 | O15118 | 5/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31337274 | 0.86 | HPGD (1.00) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL7159563 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HPGDRAB9AMAPTTHRB | |
| SCHEMBL3201536 | 0.79 | ALDH1A1 (0.83) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL3200646 | 0.78 | HPGD (0.66) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL6360984 | 0.78 | ALDH1A1 (0.80) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL28958744 | 0.77 | MAPT (0.61) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL28958700 | 0.77 | ALDH1A1 (0.73) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL10707325 | 0.76 | ALDH1A1 (0.83) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| SCHEMBL4020988 | 0.76 | RAB9A (0.70) | ALDH1A1HPGDRAB9ANPC1MAPT | |
| Hydrochloric Acid SCHEMBL10710405 | 0.76 | ALDH1A1 (0.77) | ALDH1A1HPGDRAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030232841-A1 | Heterocyclic carboxamides | PFIZER INC | 2003-12-18 | — | — | US | disclosed |
| US-6602874-B2 | 5-(2-(4-methylpiperazin-1-yl)-phenyl)- furan-2-carboxylic acid 4-chlorobenzylamide, for example; treating or preventing migraine, depression and other disorders for which a 5-HT1, agonist or antagonist is indicated | PFIZER INC. | 2003-08-05 | — | — | US | disclosed |
| US-6537995-B2 | Selective serotonin receptor agonists and antagonists used to treat migraines, depression, anxiety and schizophrenia; sertraline | PFIZER INC. | 2003-03-25 | — | — | US | disclosed |
| EP-0957099-B1 | Heterocyclic carboxamides | PFIZER PROD INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-20020002168-A1 | Heterocyclic carboxamides | HOWARD HARRY R (US) | 2002-01-03 | — | — | US | disclosed |
| US-20010041705-A1 | Heterocyclic carboxamides | HOWARD HARRY R (US) | 2001-11-15 | — | — | US | disclosed |
| US-6277852-B1 | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-0957099-A2 | Heterocyclic carboxamides | Pfizer Products Inc. (US) | 1999-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002168-A1 | Heterocyclic carboxamides | HTR1A, HTR1D, NPY1R | ALDH1A1 1831/4885HPGD 691/4885RAB9A 2435/4885 |
| US-20030232841-A1 | Heterocyclic carboxamides | HTR1A, HTR1D, NPY1R | ALDH1A1 1831/4885HPGD 691/4885RAB9A 2435/4885 |
| US-20010041705-A1 | Heterocyclic carboxamides | HTR1A, HTR1D, NPY1R | ALDH1A1 1831/4885HPGD 691/4885RAB9A 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.