Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 10/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.39 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012066 | 0.93 | SLC6A4 (0.43) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL7568500 | 0.82 | CYP2D6 (0.48) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL7464514 | 0.82 | SLC6A2 (0.48) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL1012743 | 0.82 | SLC6A2 (0.48) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL7156275 | 0.81 | OPRM1 (0.47) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL3656139 | 0.80 | ALDH1A1 (0.47) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL5730907 | 0.80 | OPRM1 (0.40) | OPRM1 | |
| SCHEMBL8347022 | 0.78 | HRH3 (0.37) | SLC6A4SLC6A3SLC6A2OPRM1 | |
| SCHEMBL7160342 | 0.77 | ALDH1A1 (0.35) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL15956392 | 0.74 | OPRM1 (0.46) | SLC6A4SLC6A3SLC6A2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6537522-B1 | Metabolically stable cocaine analogs such as 2-carbometh-oxy-3-(4-iodophenyl)-tropane; chemical intermediates for compounds having high affinities for dopamine and serotonin reuptake sites in brain | AMERSHAM PLC (GB) | 2003-03-25 | — | — | US | disclosed |
| EP-0703791-B1 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RES BIOCHEMICALS LTD PATERNERS (US) | 2002-12-04 | — | — | EP | disclosed |
| US-5750089-A | Halogenated neuroprobe for mapping monoamine reuptake sites | NEURO IMAGING TECHNOLOGIES, LLC (US) | 1998-05-12 | — | — | US | disclosed |
| US-5698179-A | Iodinated neuroprobe for mapping monoamine reuptake sites | NEURO IMAGING TECHNOLOGIES, LLC (US) | 1997-12-16 | — | — | US | disclosed |
| EP-0703791-A4 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RES BIOMED LP (US) | 1996-05-22 | — | — | EP | disclosed |
| EP-0703791-A1 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RESEARCH BIOMEDICALS LIMITED PARTNERSHIP (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5439666-A | Central nervous system | RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) | 1995-08-08 | — | — | US | disclosed |
| WO-1995001184-A1 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) | 1995-01-12 | — | — | WO | disclosed |
| US-5310912-A | Ester-substituted nortropane | RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) | 1994-05-10 | — | — | US | disclosed |