SCHEMBL1012066

SCHEMBL1012066

COC(=O)C1(c2ccc(I)cc2)CC2CCC(C1)N2C

nearest known ligand 0.44

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 9/20 0.43
SLC6A3 Q01959 9/20 0.43
SLC6A2 P23975 6/20 0.43
OPRM1 P35372 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cadaverine Tartrate SCHEMBL7157449 0.93 SLC6A4 (0.39) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL7568500 0.86 CYP2D6 (0.48) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL5730907 0.86 OPRM1 (0.40) OPRM1
SCHEMBL3656139 0.86 ALDH1A1 (0.47) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL7464514 0.86 SLC6A2 (0.48) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL1012743 0.86 SLC6A2 (0.48) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL7156275 0.84 OPRM1 (0.47) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL8347022 0.84 HRH3 (0.37) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL7160342 0.83 ALDH1A1 (0.35) SLC6A4SLC6A3SLC6A2
SCHEMBL15956392 0.80 OPRM1 (0.46) SLC6A4SLC6A3SLC6A2OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9585976-B2 Automated radiolabelling method GE HEALTHCARE LIMITED (GB) 2017-03-07 US claimed
WO-2023219199-A1 MANUFACTURING METHOD FOR FP-CIT PRECURSOR, AND MANUFACTURING METHOD FOR [18F]FP-CIT USING FP-CIT PRECURSOR MANUFACTURED THEREBY (주)듀켐바이오 2023-11-16 WO disclosed
EP-1118674-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE TROPINONE MONOCARBOXYLIC ACID DERIVATIVE NIHON MEDIPHYSICS CO LTD (JP) 2011-01-05 EP disclosed
EP-2212320-A1 CHEMICAL SYNTHESIS OF I-124BETA CIT IODINE-124 [2-BETA-CARBOMETHOXY-3BETA- (4. -IODOPHENYL) -TROPANE] FOR PET INVESTIGATIONS AND FOR RADIOTHERAPY A.C.O.M. Advanced Center Oncology Macerata S.p.a. (IT) 2010-08-04 EP disclosed
EP-2212320-A1 CHEMICAL SYNTHESIS OF I-124BETA CIT IODINE-124 [2-BETA-CARBOMETHOXY-3BETA- (4. -IODOPHENYL) -TROPANE] FOR PET INVESTIGATIONS AND FOR RADIOTHERAPY A.C.O.M. Advanced Center Oncology Macerata S.p.a. (IT) 2010-08-04 EP disclosed
WO-2009143985-A1 NEW MOLECULE 5-HYDROXY-L-(4-HYDROXY-3-[124I]IODO-5-METHOXYPHENYL)-7- (4-HYDROXY-3-METHOXYPHENYL)-L,4,6-HEPTATRIEN-3-ONE FOR PET INVESTIGATIONS AND RADIOTHERAPY. SPARKLE S.R.L. (IT) 2009-12-03 WO disclosed
WO-2009141137-A2 NEW MOLECULE [124I][2-(3'-IODO-4'-METHYLAMINOPHENYL)-6-HYDROXY-BENZOTHIALZOLE] FOR PET INVESTIGATIONS AND RADIOTHERAPY SPARKLE S.R.L. (IT) 2009-11-26 WO disclosed
WO-2009046897-A1 CHEMICAL SYNTHESIS OF I-124BETA CIT IODINE-124 [2-BETA-CARBOMETHOXY-3BETA- (4. -IODOPHENYL) -TROPANE] FOR PET INVESTIGATIONS AND FOR RADIOTHERAPY A.C.O.M ADVANCED CENTER ONCOLOGY MACERATA S.P.A. (IT) 2009-04-16 WO disclosed
WO-2009046897-A1 CHEMICAL SYNTHESIS OF I-124BETA CIT IODINE-124 [2-BETA-CARBOMETHOXY-3BETA- (4. -IODOPHENYL) -TROPANE] FOR PET INVESTIGATIONS AND FOR RADIOTHERAPY A.C.O.M ADVANCED CENTER ONCOLOGY MACERATA S.P.A. (IT) 2009-04-16 WO disclosed
US-20030065183-A1 Process for producing optically active tropinonemonocarboxylic acid ester derivative NIHON MEDI-PHYSICS CO., LTD. 2003-04-03 US disclosed
EP-1118674-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE TROPINONE MONOCARBOXYLIC ACID DERIVATIVE Nihon Medi-Physics Co., Ltd. (JP) 2001-07-25 EP disclosed
US-5750089-A Halogenated neuroprobe for mapping monoamine reuptake sites NEURO IMAGING TECHNOLOGIES, LLC (US) 1998-05-12 US disclosed
EP-0831941-A1 IODINATED NEUROPROBES FOR MAPPING MONOAMINE REUPTAKE SITES Research Biochemicals, Limited Paternership, doing business as Research biochemicals International (US) 1998-04-01 EP disclosed
US-5698179-A Iodinated neuroprobe for mapping monoamine reuptake sites NEURO IMAGING TECHNOLOGIES, LLC (US) 1997-12-16 US disclosed
WO-1996039198-A1 IODINATED NEUROPROBES FOR MAPPING MONOAMINE REUPTAKE SITES RESEARCH BIOCHEMICALS, LIMITED PARTNERSHIP, doing business as RESEARCH BIOCHEMICALS INTERNATIONAL, A MASSACHUSETTS LIMITED PARTNERSHIP, WHOSE SOLE GENERAL PARTNER IS RBI MANAGEMENT, INC. (US) 1996-12-12 WO disclosed
EP-0703791-A4 AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES RES BIOMED LP (US) 1996-05-22 EP disclosed
EP-0703791-A1 AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES RESEARCH BIOMEDICALS LIMITED PARTNERSHIP (US) 1996-04-03 EP disclosed
US-5439666-A Central nervous system RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) 1995-08-08 US disclosed
WO-1995001184-A1 AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) 1995-01-12 WO disclosed
US-5310912-A Ester-substituted nortropane RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) 1994-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030065183-A1 Process for producing optically active tropinonemonocarboxylic acid ester derivative CES2, FTO, HAAO SLC6A4 1204/4885SLC6A3 712/4885SLC6A2 1485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.