Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4879959 | 0.75 | KDM4E (0.59) | ALDH1A1MAPTHTTKDM4EHPGD | |
| SCHEMBL4880800 | 0.71 | MAPT (0.79) | ALDH1A1MAPTHTTFLT1FLT4 | |
| SCHEMBL714553 | 0.71 | ACLY (0.38) | ALDH1A1MAPTKDM4ETDP1MEN1 | |
| SCHEMBL13797489 | 0.70 | TRPV4 (0.48) | ALDH1A1MAPTHTTHPGDHSD11B1 | |
| SCHEMBL715945 | 0.69 | MAPT (0.51) | ALDH1A1MAPTHTTHSD17B10FLT1 | |
| SCHEMBL23251426 | 0.68 | TRPV4 (0.47) | ALDH1A1MAPTHTTHSD11B1TRPV4 | |
| SCHEMBL6558665 | 0.68 | KMT2A (0.50) | ALDH1A1MAPTHTTKDM4EHPGD | |
| SCHEMBL11225782 | 0.67 | ALDH1A1 (0.64) | ALDH1A1MAPTHTTKDM4EHPGD | |
| SCHEMBL4175248 | 0.67 | KDM4E (0.56) | ALDH1A1MAPTHTTKDM4EHSD11B1 | |
| SCHEMBL9732423 | 0.67 | TRPV4 (0.46) | MAPTHPGDHSD11B1TRPV4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120052057-A9 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2012-03-01 | — | — | US | claimed |
| US-20110150859-A1 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2011-06-23 | — | — | US | claimed |
| EP-2140029-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | Biotie Therapies Corp. (FI) | 2010-01-06 | — | — | EP | claimed |
| WO-2008125738-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-23 | — | — | WO | claimed |
| US-20120052057-A9 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2012-03-01 | — | — | US | disclosed |
| US-20110150859-A1 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2011-06-23 | — | — | US | disclosed |
| EP-2140029-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | Biotie Therapies Corp. (FI) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008125738-A2 | A METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2008-10-23 | — | — | WO | disclosed |