Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159601 | 0.89 | ACHE (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7228596 | 0.84 | ACHE (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7159560 | 0.81 | ROCK2 (0.38) | ACHEMAPK1LMNAGAAHTT | |
| SCHEMBL7098179 | 0.81 | ALDH1A1 (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL6784764 | 0.79 | S1PR1 (0.36) | GAAHTTSMN1; SMN2KMT2AKMO | |
| SCHEMBL6929116 | 0.77 | CASR (0.39) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7104909 | 0.76 | GRM8 (0.43) | HTTSMN1; SMN2KMT2AGRM4PKM | |
| SCHEMBL7247069 | 0.74 | ADRB3 (0.43) | MAPK1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL21624997 | 0.74 | CHEK2 (0.35) | — | |
| SCHEMBL632963 | 0.73 | DYRK1A (0.36) | DYRK1AMAPK1KMT2ANFKB1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |