Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159560 | 0.89 | ROCK2 (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7161306 | 0.84 | ACHE (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7159601 | 0.81 | ACHE (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7098179 | 0.81 | ALDH1A1 (0.38) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7162387 | 0.79 | RXRA (0.30) | — | |
| SCHEMBL6929116 | 0.77 | CASR (0.39) | ACHELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL7104909 | 0.76 | GRM8 (0.43) | HTTSMN1; SMN2GRM4KMT2ATSHR | |
| SCHEMBL7247069 | 0.74 | ADRB3 (0.43) | SMN1; SMN2KMT2A | |
| SCHEMBL7158323 | 0.74 | PDE2A (0.38) | — | |
| SCHEMBL21624997 | 0.74 | CHEK2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667335-B2 | NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers | HOFFMANN-LA ROCHE INC. | 2003-12-23 | — | — | US | disclosed |