Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946753 | 0.78 | GPR84 (0.44) | ADORA1ADORA2AADORA3GSK3BGPR84 | |
| SCHEMBL11297462 | 0.78 | GPR84 (0.44) | ADORA1ADORA2AADORA3GSK3BGPR84 | |
| SCHEMBL8016347 | 0.77 | TLR8 (0.47) | GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL4814536 | 0.75 | GPR84 (0.42) | ADORA1ADORA2AADORA3GSK3BGPR84 | |
| SCHEMBL6618330 | 0.74 | GSK3B (0.44) | ADORA1ADORA2AADORA3GSK3BGPR84 | |
| Ammonia Solution, Strong SCHEMBL27564785 | 0.73 | GSK3B (0.43) | ADORA1ADORA2AADORA3GSK3BGPR84 | |
| SCHEMBL7100910 | 0.72 | GSK3B (0.41) | PDGFRBGSK3BTSHRNPSR1HSD17B10 | |
| SCHEMBL8012182 | 0.72 | TLR8 (0.44) | GSK3BALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL13277717 | 0.72 | GSK3B (0.43) | ADORA1ADORA2AADORA3ADORA2BGSK3B | |
| SCHEMBL6965532 | 0.72 | PDGFRB (0.48) | PDGFRBDRD2HTR6ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |