Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11297462 | 0.97 | GPR84 (0.44) | GPR84SMN1; SMN2MAPTTP53DHFR | |
| SCHEMBL2946753 | 0.97 | GPR84 (0.44) | GPR84SMN1; SMN2MAPTTP53DHFR | |
| SCHEMBL6618330 | 0.91 | GSK3B (0.44) | GPR84SMN1; SMN2MAPTTP53HSD11B1 | |
| Ammonia Solution, Strong SCHEMBL27564785 | 0.89 | GSK3B (0.43) | GPR84SMN1; SMN2MAPTTP53HSD11B1 | |
| Benzylamine SCHEMBL28750130 | 0.88 | TLR8 (0.42) | GPR84SMN1; SMN2MAPTTP53DHFR | |
| SCHEMBL1926476 | 0.87 | SIGMAR1 (0.48) | MAPTTLR8NPC1ALDH1A1STAT1 | |
| SCHEMBL1917870 | 0.84 | ADORA3 (0.50) | SMN1; SMN2MAPTTP53TLR8NPC1 | |
| SCHEMBL8016347 | 0.84 | TLR8 (0.47) | SMN1; SMN2MAPTTLR8ALDH1A1RAB9A | |
| SCHEMBL27815847 | 0.83 | HSD11B1 (0.50) | GPR84MAPTTP53HSD11B1KCNH2 | |
| SCHEMBL27835295 | 0.83 | HSD11B1 (0.50) | GPR84MAPTTP53HSD11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402602-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2008-07-22 | — | — | US | claimed |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) | 2007-05-03 | — | — | US | claimed |
| US-7157483-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-01-02 | — | — | US | claimed |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCRAS | 2006-03-30 | — | — | US | claimed |
| EP-1401432-B1 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOD CONSEILS RECH APPLIC (FR) | 2005-09-14 | — | — | EP | claimed |
| JP-2005500297-A | — | — | 2005-01-06 | — | — | JP | claimed |
| EP-1401432-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2004-03-31 | — | — | EP | claimed |
| WO-2002102375-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2002-12-27 | — | — | WO | claimed |
| US-7402602-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2008-07-22 | — | — | US | disclosed |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) | 2007-05-03 | — | — | US | disclosed |
| US-7157483-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCRAS | 2006-03-30 | — | — | US | disclosed |
| EP-1401432-B1 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOD CONSEILS RECH APPLIC (FR) | 2005-09-14 | — | — | EP | disclosed |
| US-20040198792-A1 | Imidazole derivatives modulating the sodium channels | IPSEN PHARMA S.A.S. (FR) | 2004-10-07 | — | — | US | disclosed |
| EP-1401432-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002102375-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198792-A1 | Imidazole derivatives modulating the sodium channels | SCN1A, SCN1B, TRPV1 | GPR84 1535/4885SMN1; SMN2 718/4885MAPT 474/4885 |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SCN2B, KCNJ2, SCN1B | GPR84 1788/4885SMN1; SMN2 968/4885MAPT 2473/4885 |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCN1B, SCN1A, SCN2B | GPR84 2060/4885SMN1; SMN2 441/4885MAPT 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.