Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.47 |
| ▸ | TK1 | P04183 | 4/20 | 0.41 |
| ▸ | NT5E | P21589 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | GAPDH | P04406 | 1/20 | 0.35 |
| ▸ | TK2 | O00142 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162036 | 0.90 | MEN1 (0.38) | RNASE1TK1NT5EALDH1A1HTT | |
| SCHEMBL7162782 | 0.86 | NT5E (0.47) | NT5EPOLBMEN1USP2KMT2A | |
| SCHEMBL7037107 | 0.82 | NT5E (0.44) | NT5EALDH1A1POLBMEN1USP2 | |
| SCHEMBL8427016 | 0.80 | NT5E (0.39) | NT5EPOLBMEN1USP2KMT2A | |
| SCHEMBL7158742 | 0.79 | MEN1 (0.37) | NT5EALDH1A1POLBMEN1USP2 | |
| SCHEMBL7157425 | 0.79 | NT5E (0.40) | NT5EALDH1A1HTTPOLBMEN1 | |
| SCHEMBL7165048 | 0.79 | ALDH1A1 (0.36) | NT5EALDH1A1HTTPOLBMEN1 | |
| SCHEMBL7035782 | 0.78 | NT5E (0.41) | NT5EPOLBMEN1USP2KMT2A | |
| SCHEMBL7161171 | 0.78 | NT5E (0.43) | RNASE1NT5EALDH1A1POLBMEN1 | |
| SCHEMBL7161805 | 0.77 | POLB (0.41) | RNASE1NT5EALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747389-B1 | 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-RE38090-E1 | Antitumor activity; useful for treatment and prevention of cancers | Matsuda, Akira (JP) | 2003-04-22 | — | — | US | disclosed |
| US-5763418-A | NUCLEOTIDE ANTITUMOR AGENTS | Matsuda, Akira (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0747389-A1 | 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1996-12-11 | — | — | EP | disclosed |