Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HRAS | P01112 | 1/20 | 0.30 |
| ▸ | GAPDH | P04406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162782 | 0.82 | NT5E (0.47) | MEN1USP2POLBKMT2ANT5E | |
| SCHEMBL7162036 | 0.79 | MEN1 (0.38) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7162040 | 0.79 | RNASE1 (0.47) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7037107 | 0.78 | NT5E (0.44) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7157425 | 0.78 | NT5E (0.40) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7164410 | 0.76 | ALDH1A1 (0.40) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7165048 | 0.76 | ALDH1A1 (0.36) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7161077 | 0.75 | ALDH1A1 (0.39) | ALDH1A1NPC1 | |
| SCHEMBL26801671 | 0.74 | MEN1 (0.62) | MEN1USP2POLBKMT2AALDH1A1 | |
| SCHEMBL7038066 | 0.73 | MEN1 (0.41) | MEN1POLBKMT2AALDH1A1GAPDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747389-B1 | 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-RE38090-E1 | Antitumor activity; useful for treatment and prevention of cancers | Matsuda, Akira (JP) | 2003-04-22 | — | — | US | disclosed |
| US-5763418-A | NUCLEOTIDE ANTITUMOR AGENTS | Matsuda, Akira (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0747389-A1 | 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1996-12-11 | — | — | EP | disclosed |