Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.45 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748617 | 0.78 | RIPK1 (0.57) | RIPK1CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL27714279 | 0.77 | RIPK1 (0.55) | RIPK1CCNE1CDK2CDK1CCNB1 | |
| SCHEMBL26174487 | 0.74 | RIPK1 (0.57) | RIPK1CCNE1CDK2CCNT1CDK9 | |
| SCHEMBL7151357 | 0.72 | RIPK1 (0.57) | RIPK1CDK1CCNB1 | |
| SCHEMBL29460640 | 0.69 | RIPK1 (0.56) | RIPK1CDK1CCNB1 | |
| SCHEMBL1777558 | 0.68 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL15436394 | 0.68 | CDC7 (0.50) | CCNE1CDK2CCNT1CDK9CDK5 | |
| SCHEMBL3009852 | 0.68 | RIPK1 (0.74) | RIPK1CDK1CCNB1CDK5CDK5R1 | |
| SCHEMBL7168363 | 0.68 | RIPK1 (0.46) | RIPK1CCNE1CDK2 | |
| SCHEMBL16493681 | 0.68 | RIPK1 (0.45) | RIPK1CCNE1CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |