Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 3/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 5/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717696 | 0.91 | RIPK1 (0.45) | HSP90AA1HSP90AB1RIPK1SCDSCD5 | |
| SCHEMBL715644 | 0.85 | POLB (0.50) | — | |
| SCHEMBL175220 | 0.82 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1RIPK1SCDSCD5 | |
| SCHEMBL715025 | 0.80 | NAA50 (0.38) | — | |
| SCHEMBL166963 | 0.80 | RIPK1 (0.54) | HSP90AA1HSP90AB1RIPK1SCDSCD5 | |
| SCHEMBL167323 | 0.79 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1RIPK1SCDSCD5 | |
| SCHEMBL716612 | 0.76 | NPC1 (0.46) | — | |
| SCHEMBL164387 | 0.76 | PARP14 (0.60) | HSP90AA1HSP90AB1RIPK1SCDSCD5 | |
| SCHEMBL256556 | 0.72 | RIPK1 (0.53) | HSP90AA1HSP90AB1RIPK1SCDSCD5 | |
| SCHEMBL256561 | 0.72 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1RIPK1SCDSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053200-A1 | BACE 2 INHIBITORS | BACE2, BACE1, PSEN2 | HSP90AA1 3048/4885HSP90AB1 1398/4885RIPK1 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.