Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 4/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL716840 | 0.91 | HSP90AA1 (0.45) | RIPK1ROCK2HSP90AA1HSP90AB1SCD | |
| SCHEMBL716612 | 0.85 | NPC1 (0.46) | ALDH1A1 | |
| SCHEMBL168416 | 0.82 | RIPK1 (0.53) | RIPK1ROCK2HSP90AA1HSP90AB1SCD | |
| SCHEMBL164502 | 0.82 | RIPK1 (0.46) | RIPK1ROCK2HSP90AA1HSP90AB1SCD | |
| SCHEMBL166794 | 0.80 | ROCK2 (0.60) | RIPK1ROCK2HSP90AA1HSP90AB1SCD | |
| SCHEMBL716616 | 0.80 | CPT2 (0.38) | ROCK2HSP90AA1HSP90AB1TSHR | |
| SCHEMBL175220 | 0.78 | HSP90AA1 (0.46) | RIPK1ROCK2HSP90AA1HSP90AB1SCD | |
| SCHEMBL715644 | 0.77 | POLB (0.50) | ALDH1A1 | |
| SCHEMBL3960465 | 0.75 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL18143043 | 0.73 | ROCK2 (0.57) | RIPK1ROCK2HSP90AA1HSP90AB1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053200-A1 | BACE 2 INHIBITORS | BACE2, BACE1, PSEN2 | RIPK1 3784/4885ROCK2 1674/4885HSP90AA1 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.