Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770532 | 0.83 | ALOX15 (0.50) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL10661854 | 0.83 | ALDH1A1 (0.50) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL10147428 | 0.80 | TDP1 (0.44) | ALDH1A1ALOX15TDP1SMN1; SMN2TP53 | |
| SCHEMBL8212165 | 0.78 | ALDH1A1 (0.50) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL10873220 | 0.78 | ALDH1A1 (0.50) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL160721 | 0.78 | ALDH1A1 (0.50) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL6897299 | 0.77 | RAB9A (0.47) | ALDH1A1ALOX15SMN1; SMN2HPGDRAD52 | |
| SCHEMBL6843558 | 0.77 | ALDH1A1 (0.39) | ALDH1A1ALOX15HSD17B10HPGDRAD52 | |
| SCHEMBL17897876 | 0.77 | ALDH1A1 (0.48) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL6892362 | 0.77 | ALDH1A1 (0.39) | ALDH1A1ALOX15TDP1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562830-B1 | Compounds which prevent or induce the remission of existing precancerous or cancerous lesions or carcinomas would greatly reduce illness and death from cancer | CELL PATHWAYS, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-0371731-B1 | Quinazolinone derivatives | SMITH KLINE FRENCH LAB (GB) | 1994-04-20 | — | — | EP | disclosed |
| US-5147875-A | 2-(SUBSTITUTED PHENYL)-4-OXO-QUINAZOLINES | SANSHIN KOGYO KABISHIKI KAISHA (JP) | 1992-09-15 | — | — | US | disclosed |
| EP-0371731-A2 | Quinazolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-06-06 | — | — | EP | disclosed |