SCHEMBL716894

SCHEMBL716894

CC(=O)Oc1cccc(/C=C/c2ccccc2)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.60
LMNA P02545 2/20 0.60
CYP3A4 P08684 2/20 0.60
MEN1 O00255 2/20 0.60
MAPT P10636 2/20 0.60
KDM4E B2RXH2 2/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
TTR P02766 1/20 0.60
TP53 P04637 1/20 0.60
CYP19A1 P11511 1/20 0.55
TUBB4A P04350 1/20 0.53
TUBB P07437 1/20 0.53
TUBA3C P0DPH7 1/20 0.53
TUBA1B P68363 1/20 0.53
TUBA4A P68366 1/20 0.53
TUBB4B P68371 1/20 0.53
TUBB3 Q13509 1/20 0.53
TUBB2A Q13885 1/20 0.53
TUBB8 Q3ZCM7 1/20 0.53
TUBA3E Q6PEY2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL716895 1.00 KMT2A (0.60) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL719415 0.92 KMT2A (0.73) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL719416 0.92 KMT2A (0.73) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL9243490 0.89 BCHE (0.50) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL18130117 0.89 CYP3A4 (0.60) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL10149036 0.89 LMNA (0.60) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL18130118 0.89 CYP3A4 (0.60) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL8569560 0.88 KMT2A (0.54) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL718478 0.88 KMT2A (0.77) KMT2ALMNACYP3A4MEN1MAPT
SCHEMBL718479 0.88 KMT2A (0.77) KMT2ALMNACYP3A4MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11352310-B2 Prenylated hydroxystilbenes Kynan Duke IP, LLC (US) 2022-06-07 US disclosed
US-20200331833-A1 PRENYLATED HYDROXYSTILBENES THE UNIVERSITY OF SYDNEY (AU) 2020-10-22 US disclosed
US-10696615-B2 Prenylated hydroxystilbenes THE UNIVERSITY OF SYDNEY (AU) 2020-06-30 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20190194105-A1 PRENYLATED HYDROXYSTILBENES THE UNIVERSITY OF SYDNEY (AU) 2019-06-27 US disclosed
US-10196335-B2 Prenylated hydroxystilbenes THE UNIVERSITY OF SYDNEY (AU) 2019-02-05 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
EP-2391658-A1 MOLECULARLY IMPRINTED POLYMERS Commonwealth Scientific and Industrial Research Organisation (AU) 2011-12-07 EP disclosed
WO-2010085851-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-08-05 WO disclosed
WO-2010085851-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10196335-B2 Prenylated hydroxystilbenes HMGB2, CYP51A1, CYP8B1 KMT2A 3631/4885LMNA 1076/4885CYP3A4 497/4885
US-20200331833-A1 PRENYLATED HYDROXYSTILBENES HSD11B1, HSD3B1, CYP8B1 KMT2A 2339/4885LMNA 114/4885CYP3A4 216/4885
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 KMT2A 964/4885LMNA 3479/4885CYP3A4 780/4885
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 KMT2A 964/4885LMNA 3479/4885CYP3A4 780/4885
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 KMT2A 964/4885LMNA 3479/4885CYP3A4 780/4885
US-10696615-B2 Prenylated hydroxystilbenes HSD11B1, CYP8B1, NR1H2 KMT2A 1940/4885LMNA 167/4885CYP3A4 392/4885
US-11352310-B2 Prenylated hydroxystilbenes HSD11B1, HSD3B1, CYP8B1 KMT2A 2339/4885LMNA 114/4885CYP3A4 216/4885
US-20190194105-A1 PRENYLATED HYDROXYSTILBENES HSD11B1, CYP8B1, NR1H2 KMT2A 1940/4885LMNA 167/4885CYP3A4 392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.