Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 4/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758769 | 0.83 | — | — | |
| SCHEMBL1519797 | 0.82 | AR (0.32) | ARPGRKIF11 | |
| SCHEMBL146460 | 0.78 | AR (0.31) | AR | |
| SCHEMBL225599 | 0.77 | ALDH1A1 (0.48) | — | |
| SCHEMBL14483362 | 0.76 | GLA (0.38) | — | |
| SCHEMBL27618380 | 0.74 | — | — | |
| SCHEMBL101627 | 0.74 | KIF11 (0.32) | KIF11 | |
| SCHEMBL145873 | 0.74 | AR (0.32) | AR | |
| SCHEMBL14895318 | 0.74 | KIF11 (0.33) | ARKIF11 | |
| SCHEMBL9586467 | 0.73 | APP (0.43) | HSD17B1HSD17B2ARPGRKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140100194-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-04-10 | — | — | US | claimed |
| US-8558011-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA, NV (BE) | 2013-10-15 | — | — | US | claimed |
| EP-2029614-B1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-23 | — | — | EP | claimed |
| US-20120053347-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-03-01 | — | — | US | claimed |
| US-20080287398-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-20 | — | — | US | claimed |
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-31 | — | — | US | claimed |
| US-20060025345-A1 | Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-02 | — | — | US | claimed |
| WO-2005113582-A1 | SUBSTITUTED ETHANE-1,2-DIAMINES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | WO | claimed |
| CN-117586272-A | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-111615515-B | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-112979661-B | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技股份有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-113396137-A | Method for producing 1,1, 1-trifluoro-2, 2-bisarylethane, and 1,1, 1-trifluoro-2, 2-bisarylethane | 中央硝子株式会社 | 2021-09-14 | — | — | CN | disclosed |
| CN-112979661-A | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-111615515-A | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技有限公司 | 2020-09-01 | — | — | CN | disclosed |
| US-4459405-A | Desacetylcephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1984-07-10 | — | — | US | disclosed |
| EP-0109816-A1 | N-substituted-2-(R)-(sulfinic acid)-3-(S)-(acylamido)-4-oxo-azetidines and process | ELI LILLY AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| EP-0109817-A2 | Process for preparing oxazolinoazetidinones | ELI LILLY AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| EP-0109301-A2 | 7-(S)-acylaminocephalosporin sulfones and process | ELI LILLY AND COMPANY (US) | 1984-05-23 | — | — | EP | disclosed |
| EP-0109300-A2 | Desacetylcephalosporin sulfones | ELI LILLY AND COMPANY (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4436596-A | N-Substituted-2-(R)-(sulfinic acid)-3-(S)-(acylamido)-4-oxo-azetidines and process | ELI LILLY AND COMPANY (US) | 1984-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | HSD17B1 2127/4885HSD17B2 2674/4885AR 1496/4885 |
| US-20060025345-A1 | Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease | PSEN1, PSEN2, APP | HSD17B1 2195/4885HSD17B2 2252/4885AR 664/4885 |
| US-20120053347-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | HSD17B1 2127/4885HSD17B2 2674/4885AR 1496/4885 |
| US-20080287398-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | HSD17B1 2127/4885HSD17B2 2674/4885AR 1496/4885 |
| US-20140100194-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | HSD17B1 2127/4885HSD17B2 2674/4885AR 1496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.