Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136125 | 0.80 | LMNA (0.54) | HSPB1ATMTDP1ALDH1A1MAPT | |
| SCHEMBL1136339 | 0.79 | NPC1 (0.54) | HSPB1ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL232059 | 0.78 | ALDH1A1 (0.61) | HSPB1ATMTDP1ALDH1A1L3MBTL1 | |
| SCHEMBL1136016 | 0.78 | MAPT (0.53) | HSPB1ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL22025631 | 0.77 | MAPT (0.47) | TDP1ALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL31637112 | 0.77 | MEN1 (0.44) | ALDH1A1L3MBTL1MAPTKMT2AHPGD | |
| SCHEMBL27778849 | 0.77 | HSPB1 (0.48) | HSPB1ATMTDP1ALDH1A1L3MBTL1 | |
| SCHEMBL16388497 | 0.76 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1MAPTKMT2A | |
| SCHEMBL28053828 | 0.75 | L3MBTL1 (0.43) | TDP1ALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL6771960 | 0.75 | HSPB1 (0.49) | HSPB1ATMTDP1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573377-B1 | Antitumor agent capable of showing its efficacy even against 5- FU drug resistant tumors | DAIICHI PHARMACEUTICALS CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1103551-A1 | PYRAZOLE DERIVATIVES AND SALTS THEREOF | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-05-30 | — | — | EP | disclosed |