Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 9/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172621 | 0.98 | MMP8 (0.46) | MMP8KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL7177458 | 0.89 | MMP8 (0.52) | MMP8KDM4EALDH1A1TACR2CTSS | |
| SCHEMBL7185090 | 0.87 | MMP8 (0.55) | MMP8ALDH1A1TACR2RENCTSS | |
| SCHEMBL7177453 | 0.84 | MMP3 (0.55) | MMP8 | |
| SCHEMBL7172650 | 0.83 | NPC1 (0.47) | KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL7170036 | 0.82 | MMP2 (0.57) | MMP8 | |
| SCHEMBL7178370 | 0.81 | PPARG (0.46) | KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL7174719 | 0.81 | NPC1 (0.45) | KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL7178527 | 0.79 | NPC1 (0.43) | KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL7178513 | 0.79 | MMP1 (0.44) | MMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |
| EP-1005449-B1 | 3-ARYL-SUCCINAMIDO-HYDROXAMIC ACIDS, METHODS FOR PRODUCING SAID ACIDS AND MEDICAMENTS CONTAINING THE SAME | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0897908-A1 | 3-Aryl-succinamido-hydroxamic acids, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-02-24 | — | — | EP | disclosed |